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This page is devoted to a selection of replies to our Survey

"an inherited disease of Staffordshire Bull Terriers and other breeds"




Symptoms that led you to go to the vet/get tested


1. No symptoms

2. Pacing , howling, wanting to get outside, hunting for food all these things just happened at once as though a switch had been flipped in his brain and very out of character

3. Wobbly gait, muscle stiffness in tummy/back/thighs, exercise intolerance which results in the muscle stiffness

4. Strange behaviour after 2nd operation for cherry eye. Panting, retching, walking backwards, disorientation, panicked look. In retrospect we see that Foxy had had "fits" since we first got her at 14 months. We thought it was due to stress of being outside after not being walked much, particularly as the fits all but disappeared over the next few months as she built up muscle and confidence. Early warning signs of a potential fit is bobbing of the head, then arched back and stiff legs. If we are quick enough, I think we have managed to lessen/avoid an attack by massage and soft spoken reassurance. We also noticed that she jumps up on the bed funny - vertical rather than with a forward motion - is uncoordinated when running, and no paw/eye coordination when playing retrieve.

5. As a puppy Jake had intermittent fits causing his back legs to lift up and flip over, he had no more than 1 fit every other month until 2010 and he had a cluster fit that lasted all night. Our vet was unable to give us a diagnosis so we were referred to a specialist neurologist and after 1 week of Jake being hospitalised L2HGA was diagnosed.

6. Unusual gait, incordination. legs xrayed and ok. Test for L2HGA and positive. No brain "turns" until 2008 (howling, sniffing non-stop, running off, in a world of her own) every 4/5 weeks. Medication started 2009, (Epiphen) after visit to Glasgow Vet School for MRI scan. Epiphen has kept her stable.

7. Ruby had presented with back spasms since about 18 months old. every time we went to vet she never did it. then in April 2013 she had a fit. she had 4 fits over the weekend. she was then taken to Manchester where was diagnosed with either a tumour, meningitis or epilepsy. after a week there she came home, I sent of for the swabs from AHT.

8. Breeder notified us that litter was affected - One of first litters to have L2HGA. Sera had some mood issues - depression, difficulty potty training, getting lost in closets prior to diagnosis, but little else in terms of symptoms


Age at diagnosis: 1. 1 year old, 2. 3 years 4 months, 3.  2 years old, 4. 3 years old, 5. 6 years old, 6. 14 months, 7. 5 years old, 8. 1 year old


Give details regarding daily life for you and your pet with L2 HGA


1. Very normal, slightly hyperactive

2. Daily life with Badger was fine his illness was controlled with vitamins and steroids. The steroids were given for suspected meningitis at the same time as l2 was diagnosed we were told to wean him off the steroids because not good for long term use and had never really been used to treat l2 but every time we tried he would have a mad episode again. We decided to give him steroids long term we thought they were helping him we tried numerous times to wean him off but the same thing would happen. so life with steroids was fine he would have tired days, and sad days but the good very much out weighed the bad.

3. Used to be really hard. Now Brooke is on steroids once every other day and a product called KalmAid when needed.

4. We have a calm, quiet, household (2 adults, 3 cats, 2 dogs) but Foxy copes well with visitors, even if she is a bit too excited. Walked daily for 30-40 minutes, off lead whenever possible. Fed twice daily on dried pets at home or Bakers food. Sleeps a lot. Trained (obedience) once or twice a week though this is a challenge as she is easily distracted or often "away with the fairies". She does have her bronze good citizen award though. Has company most of the day.

5. Every day life with Jake was manageable he was on 60mg of Epiphen twice a day to control his fits. He still had a few fits in this period but they weren’t so bad and we knew how to deal with them.

6. She will be 11 in January. Showing her age now. Unable to walk too far on concrete, nails wear down due to her gait and bleed. Very excited to run on the grass, back legs flying behind her. she sometimes falls over. Back legs very wobbly in the evening looks as though she will collapse. Some evenings very unsettled, walks round and round, in and out of her bed. medicine 2 x day. very excited at meal times, panting etc. always wants food, think due to medicine.

7. Ruby isn't the same dog. She's on Epiphen and potassium bromide to keep the fits at bay. we managed to reduced the Epiphen but had started fitting every 3 weeks so she is now on the highest dose possible. we haven't had a fit since the beginning of November. She has put on weight due to Epiphen and the steroids she was on. her legs give way daily. she gets stuck in corners, under tables etc. presses her head onto legs on the side of the settee. we think her vision has been affected as she seems to feel for her dog food. she circles constantly which gets worse at night. we can't let her get excited as it brings a fit on, even playing with her football. she struggles to get up and down steps out of house. she has taken to eating the contents of the cat litter tray and even her own faeces. we aren't sure how long she or we can carry on, its constantly worrying about her and listening out for her.

8. Sera was afraid of everything. She developed stress-induced seizures around age 4. By age 6, she had multiple Gran Mals a week always in the middle of the night. She lived 5 years more on KBr [potassium bromide] therapy for seizures and valium prescription for fear. She had exercise intolerance beginning at age 3. She could not walk for more than 15 - 20 minutes without severe arching of the back and stiffness of hindquarters. We chose KBr therapy rather than phenobarbital because Sera also had a genetically small liver and had trouble with toxicity. KBr was processed through kidneys. It was very effective in seizure control. Life with Sera was constant diligence to keep her calm and secure and as healthy as possible - like a special needs child. Vets here know NOTHING about L2HGA. We moved quite a bit in the decade of her life and had to constantly be her advocate with vets.


Please give details with regards to the final stages of your pet's life before they passed away/were euthanised. If possible please provide approx age.


1. Run over age 4. no noticeable l2 symptoms. had cramp occasionally which may have been due to l2

2. The final stages of Badgers life was just a slow but steady deterioration of his character became sad not very loving didn't want to be touched just slowly we began to realise he was slipping away not himself than at the end two years after diagnosis he became aggressive towards us and our children which was never ever the case he had never bitten anyone or another dog it was than we decided to put him to sleep he wasn't happy or comfortable

3. Still alive, I hope for many more years

4. Thankfully, still with us.

5. Jake had to be euthanised on 18/11/13 as he had a fit that just didn’t stop, we gave him 15mg of Diazepam but it had no affect, we had to take him to the out of hours vet that agreed there was nothing that we could do for him.

6 and 7. Still alive

8. Sera was euthanized at age 11.5 in Oct 2013. Ultimately, neurological damage made constant tremors, especially at night, even with KBr treatment. She went on Tramadol after surgery for a parathyroid tumor at age 11 and we discovered the painkillers lessened the tremors. She stayed on these painkillers daily for 6 months until her death. She went downhill quickly, apparently in muscular pain and extreme nerve sensitivity. She would hide in her kennel all day and had no joy, only fear. Even petting her seemed painful for her to be touched - as if her nerves were inflamed all over her body. We decided she should no longer live in fear and pain and has her put to rest. We loved her very much.