CLEAR: the dog has 2 copies of the normal gene and will neither develop L-2-HGA, nor pass a copy of the L-2-HGA gene to any of its offspring.
CARRIER: the dog has one copy of the normal gene and one copy of the mutant gene that causes L-2-HGA. It will not develop L-2-HGA but will pass on the L-2-HGA gene to 50% (on average) of its offspring.
AFFECTED: the dog has two copies of the L-2-HGA mutation and is affected with L-2-HGA. It will develop L-2-HGA at some stage during its lifetime, assuming it lives to an appropriate age.
In the UK there are two groups of Staffordshire Bull Terriers; a group which are routinely tested prior to breeding, and those that are not. Information about tested dogs that are Kennel Club registered shows that these dogs, which are mostly 'show' or breeding dogs are virtually clear of L2HGA. The occurenc of L2HGA in historically untested dogs has not altered since testing began in 2008. In these dogs about 10-15% are considered to be carriers of the L2HGA mutation. By testing both male and female dogs before breeding, owners can be sure that the pups are 'hereditarily clear' - they cannot have the mutation. If just the male or female are tested, to save money, the pups will not have symptoms of L2HGA but could still be carriers.
Carriers can still be bred to clear dogs. On average, 50% of such a litter will be clear and 50% carriers
In the UK, tests for L2HGA are run at The Animal Health trust.
Samples submitted should be cheek swabs ( a non-invasive sampling method). Sampling kits are obtainable from the Animal Health Trust webshop www.ahtdnatesting.co.uk/canine_tests. Further information can be obtained by emailing firstname.lastname@example.org